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NO helps blood vessels widen in several ways: It reduces calcium release from smooth muscle cells' sarcoplasmic reticulum It helps put calcium back into the sarcoplasmic reticulum The cGMP pathway reduces smooth muscle tension [1] These actions work together to widen blood vessels and improve l-arginine blood flow [11]

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Figure 9 Some of the GLP-1R populations in the brain are involved in reward-related feeding behavior

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