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In our systematic review and meta-analysis evaluating the clinical efficacy and safety of combinations of DPP-4 inhibitors and SGLT2 inhibitors in patients with inadequately controlled type 2 diabetes, the combination of an SGLT2 inhibitor and a DPP-4 inhibitor showed a greater reduction in HbA1c (weighted mean difference, 0.6%), fasting plasma glucose, and 2-hour postprandial plasma glucose levels than the combination of a placebo with a DPP-4 inhibitor [47]

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[00:12:04] But I think what's often missed is something called a fasting insulin level, because about 10 years before your hemoglobin A1c will go up, a lot of Americans will develop insulin resistance

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