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Vascular lesions include diffuse and spontaneous relapsing petechial purpura, orthostatic acrocyanosis, hemorrhagic suffusions of mesothelial surfaces, and intestinal mucosa associated with chronic hemorrhagic diarrhea [148]

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Although these secretions have been proposed to fine-tune synaptic transmission and support neuronal metabolism, the precise mechanisms and physiological relevance of gliotransmission remain a matter of active debate 15,16,17

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