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Randomized controlled trials have demonstrated that semaglutide treatment does not increase overall cancer risk [3], while observational studies have revealed varying effects across different cancer types [4, 5]

Lei, G., Zhuang, L

10.2337/diabetes.48.1.86 19 FanJ.ShenW.LeeS

However, results from prior phase 2 studies in treatment-experienced GT3-infected patients without cirrhosis treated for 12 weeks demonstrated a similar tendency toward lower efficacy, with an SVR12 rate of 89% (24/27) with two relapses.[21] Notably, the 16-week regimen of G/P is now approved by the US Food and Drug Administration and the European Medicines Agency for the treatment of GT3-infected patients with prior treatment experience (with or without cirrhosis), supported by data from prior phase 2 studies and this phase 3 study, demonstrating an overall 96% (66/69) SVR12 rate in this subpopulation.[20] Among patients with baseline NS5A polymorphisms and compensated cirrhosis (n = 15, including 5 with Y93H at baseline), all achieved SVR12

Any subsequent testing may give misleading results if wrong or insufficient samples are taken or a poor sampling technique is used