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WHO recommends long-term treatment for obesity with GLP-1s in first-ever guidelines The guidelines highlight a shift to viewing obesity as a chronic illness, but safety evidence for GLP-1s remains limited

for others, it might involve using the medications to achieve initial weight loss and then transitioning to a maintenance strategy with periodic medication use as needed

A study comparing semaglutide and liraglutide found that semaglutide led to greater average weight loss (5.1% of body weight) compared to liraglutide (2.2%)