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However, the initially assumed cause for the prevention of early apoptosis, namely declining ATP levels, could not be confirmed [55]
[31] A more complete understanding of its role in physiology and disease was not established until the 1970s, when a specific radioimmunoassay was developed
The first head-to-head clinical trial (SURMOUNT-5, published in NEJM 2025) showed tirzepatide produced 20.2% average weight loss at 72 weeks versus 13.7% for semaglutide approximately 47% greater relative weight loss
as a result, they found that only 6.3% of cases had IAS among patients treated with methimazole [42], which is in agreement with the low incidence rate of IAS in Taiwan [43]
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