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What can remain includes: counterions residual salts formulation related components These may not show up clearly in standard COAs, but they still affect: pH solubility behaviour in solution pH shift during reconstitution A lyophilised peptide exists in a controlled dry state

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"Depletion of phospholipid hydroperoxide glutathione peroxidase up-regulates arachidonate metabolism by 12S-lipoxygenase and cyclooxygenase 1 in human epidermoid carcinoma A431 cells"