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Regulatory and market barriers: Reluctance from pharmaceutical companies to invest in costly trials and difficulties in demonstrating superiority over conventional therapies impede commercialization (54)

84 There were significant improvements in depressive and anxiety symptoms and CGI-S

Alternative multi-agonists for obesity treatment GLP-1R/GcgR dual agonists have shown impressive metabolic benefits and inspired the search for what now represents a growing class of rationally designed multi-agonists with differentiated mechanisms of action for obesity therapy

AMPK activation in the VMH decreases energy expenditure (105107) and AMPK inhibition increases energy expenditure ( Figure 1 )

Protein surface are colored as below: hydrophobic (white), positive charge (red), and negative charge (blue)