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These are also important for other health reasons

Diarrhea was reported in five subjects (7%) receiving VK2735 compared with four subjects (21%) receiving placebo

[Google Scholar] 4.Balasubramanian R, Maideen NM

Simultaneously, there is an increase in the expression of the dopamine transporter on neuronal cells within the limbic system (LS) and striatum, leading to more efficient reuptake and reduced availability of free dopamine in these areas

Overuse does not necessarily improve outcomes and may increase the risk of irritation