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Further studies are needed to determine if regulated expression of p21, CASP-2, CASP-9, SOD-1 and HO-1, components of the anti-oxidant glutathione metabolic pathway GP-1 and GR-1, and the DNA damage marker GADD45 are necessary to complete differentiation in specialised keratinocyte layers

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Differential expression and alternative splicing of rice sulphate transporter family members regulate sulphur status during plant growth, development and stress conditions

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[1] Another COMT inhibitor entacapone was released in 1999 which was not liver-toxic but still caused dyskinesias, nausea, diarrhea, abdominal pain, and urine discoloration