Monocytes and macrophages promote endothelial proliferation and tight junction reassembly during specific circadian phases (102), while astrocyte-derived rhythmic inflammatory factors, such as basic fibroblast growth factor, can worsen BBB dysfunction through peripheralcentral signaling (103)
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Current analogs require subcutaneous administration, and gastrointestinal side effects, particularly at higher doses, remain a concern
The drug is approved for certain types of breast cancer, but has failed to show benefit in other types of cancer
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