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Upon treatment with either a low (25 nmol/kg), medium (50 nmol/kg), or high (100 nmol/kg) dose of Lira, beclin-1 ( p = 0.014, 0.004, and 0.001, respectively) and LC3-II/LC3-I ( p = 0.004, 0.002, and 0.001, respectively) were significantly increased, while p62 levels were significantly reduced ( p = 0.155, 0.009, and 0.001, respectively) compared to MPTP-only treated mice

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These nutrients are lost through impaired absorption, increased urinary excretion, altered liver metabolism, and higher oxidative stress

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