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This approach could enable initial treatment with highly effective but expensive GLP-1 agonists, followed by maintenance with more affordable alternatives

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In addition, ~60% of the variance in the severity of the neuropsychiatric symptoms is explained by the cumulative effects of decreased SpO2 and increased PBT (thus, the severity of the acute infectious phase) coupled with increased CRP and OSTOX/ANTIOX ratio

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The FDA approved SCS devices for the treatment of painful DPN in 2022