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Blood samples were processed to either plasma (LDL-C analysis) or serum (human Fc, free PCSK9 and GLP-1R active compound analysis)

LigBuilder 2: a practical de novo drug design approach

GLP-1RAs linked to fewer major limb events The meta-analysis of 12 studies found that GLP-1RA use was associated with a 27% lower risk of major limb events in patients with type 2 diabetes and PAD compared with placebo, other glucose-lowering therapies, including SGLT-2 inhibitors and DPP-4 inhibitors, or GLP-1RA non-use