The changes in GSH levels induced by such stress are instantaneous and drastic processes, while the generation and replenishment of GSH require a lengthy process, due to involving the rate-limiting indicator glutathione synthetase [43]
Furthermore, limited target specificity has been cited as a barrier to its use as a lead compound in drug discovery ( Curcumin demonstrates a substantial ability to interact with and modulate the regulation of various proteins, growth factors, transcription factors, enzymes, receptors, and other regulatory genes through both direct and indirect mechanisms (Sohn et al., 2021)
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doi: 10.1074/jbc.C300507200 47 TabatabaieLKlompLWRubio-GozalboMESpaapenLJHaagenAADorlandLet al
10.1111/jfbc.14039 J Food Biochem
