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Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing

Dummer, P

Although Pol- has relatively low affinity for these analogues (100), their incorporation causes premature chain termination during mtDNA replication, leading to mtDNA depletion, reduced expression of -encoded OXPHOS subunits, and ultimately impaired ETC function and ATP production (101103)

Its important to inform your doctor of all medications youre taking, including over-the-counter (OTC) drugs and herbal supplements