In selected cases of severe, treatment-resistant lymphoedema, surgical options such as liposuction (covered by NICE interventional procedures guidance), lymphaticovenous anastomosis, or vascularised lymph node transfer may be considered at specialist centres, though these remain relatively uncommon
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Patil HR, Al Badarin FJ, Al Shami HA, Bhatti SK, Lavie CJ, Bell DS, OKeefe JH: Meta-analysis of effect of dipeptidyl peptidase-4 inhibitors on cardiovascular risk in type 2 diabetes mellitus