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Giulio Pasinetti M.D., Ph.D., professor of neurology at the Icahn School of Medicine at Mount Sinai agrees, saying that identifying easily obtainable biomarkers that accurately diagnose depression is an imperative for improving mental health, adding thatdepression, when undiagnosed and untreated, increases an individuals risk to develop more severe symptoms. Carla Nasca, Ph.D., a member of the McEwen lab at The Rockefeller University, the lead author on this study entitled Acetyl-L-carnitine deficiency in patients with major depressive disorder, published in the Proceedings of the National Academy of Sciences (PNAS), has been studying the role of LAC in stress and depression for years

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The rectal route of administration can be particularly useful for patients who have difficulties with oral ingestion or for those who require a rapid onset of action

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