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Studies suggest that by displacing FOXO4, the peptide releases p53 to translocate to the cytoplasm and mitochondria, where it activates Bax/Bak pore formation and caspase-mediated apoptosis
Flow Space spoke with gastrointestinal experts to understand how these drugs impact the gut and how to minimize issues through practices like eating enough fiber to avoid constipation and eating more slowly
14 These AEs can significantly impact a patients quality of life, leading to decreased adherence, limitation of dose escalations, and, in some cases, treatment discontinuation
Approximately 2030% of patients on GLP-1 receptor agonists report suboptimal weight loss or tolerability challenges, often leading them to believe the medication simply doesn't work for their body
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