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The company has not publicly confirmed a submission date, but its quarterly investor calls have consistently described retatrutide as a "late-stage pipeline priority." Lilly could also pursue a pre-NDA meeting with the FDA, where the agency provides informal guidance on what the application should contain

Restoring Ovulation in PCOS GLP-1 receptor agonists may restore ovulation by improving insulin sensitivity, reducing inflammation in the body, and lowering excess androgen levels

And they indeed appeared to reap mental health benefits in terms of reduced depression and improved quality of life, which were notably sustained to at least six months

10.1016/0024-3205(88)90468-7 112 SmithS

Knowler WC et al