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The Bottom Line Retatrutide is the most powerful weight loss drug in development, but it is not something you can get a prescription for yet

Your doctor will tailor your treatment plan and dosage to mitigate these risks

While exact published numbers from SURMOUNT-5 continue to influence clinical practice, the general pattern confirms that tirzepatide at all doses produces greater weight reduction than even maximum-dose semaglutide

Dose Reduction Strategies That Work Successful dose reduction follows predictable patterns

Patients with poorly controlled diabetes face higher risk than those achieving target HbA1c levels, emphasising the importance of optimal glycaemic management