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KERs describing increased oxidative DNA damage to inadequate DNA repair, inadequate DNA repair to increased mutations, inadequate DNA repair to increased chromosomal aberrations, and increased oxidative DNA damage to increased DNA strand breaks, while supported by non-lens evidence, are not supported by lens-based studies

McGill et al., 2012

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For example, a study of aging-related DNA methylation found hypomethylation in aged individuals compared to young populations without significant association with C677T MTHFR genotypes 30