Guijie Li, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
Tiredness may result from multiple factors including direct medication effects, inadequate caloric or nutritional intake due to reduced appetite, dehydration from gastrointestinal side effects, metabolic adaptation to weight loss, and blood sugar fluctuations in patients taking diabetes medications
Also important for endochondral ossification (cartilage-to-bone conversion during fracture healing)
Additionally, the role of the ECM, composed primarily of collagen type II and proteoglycans like aggrecan, is paramount in providing structural support and biochemical signals
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