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A randomised controlled trial of a mitochondrial therapeutic target for bipolar depression: Mitochondrial agents, N-acetylcysteine, and placebo

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Such disturbance of mitochondrial energy balance contributes to hepatocyte stress, amplifies oxidative damage, and sensitizes cells to inflammatory and apoptotic signaling in liver injury [10]

Oral and topical glutathione are generally safe, with side effects limited to mild stomach upset or rare irritation