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A single-dose study conducted by Witschi et al

HIF-1 activation leads to the transcription of genes involved in angiogenesis, glycolysis, and cell survival, facilitating tumor growth and adaptation to hypoxic conditions [108]

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100,101,102,103,104,105 miRNAs combine with Argonaute proteins to form the miRNA-induced silencing complex (miRISC), which can silence the target transcript via base pair complementation

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