10.1073/pnas.1416940111 35
Roy and members of Cytogenetics lab, BHU for providing Drosophila strains and sharing their lab facilities
(Clin Transl Med, 2021) in 24 older adults (aged 61-80) found that supplementation with GlyNAC (glycine 100 mg/kg/day + NAC 100 mg/kg/day, approximately 7 g each for a 70 kg person) for 16 weeks corrected glutathione deficiency and improved multiple hallmarks of aging including oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, body composition, exercise capacity, and cognition [10]
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The exact molecular mechanisms and functional consequences of TG2-mediated modification of cellular GSTP1 need to be further investigated