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Following its release, most B 12 is absorbed by the body in the small bowel (ileum) after binding to a protein known as intrinsic factor

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FIGURE 1 Paracellular and Transcellular BBB Permeability Molecular transport across the BBB is highly dependent on its permeability, which is defined by the paracellular pathway (molecules cross through ECs junctions) and the transcellular pathway (endocytosis followed by endosomal rearrangement and exocytosis from the cell)

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