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For example, high levels of SLC7A11-mediated Cys 2 import, in conjunction with the GSH-independent thioredoxin (Txn) system, can substitute for the essential function of the GSH-GPX4 lipid peroxide metabolic pathway in some cells both in vitro and in vivo [4244]

MC3R and MC4R are more connected to energy balance, appetite, autonomic tone, and central nervous system regulation

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