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The study showed significant decreases in HOMA2-B scores, proinsulin/insulin ratios, and proinsulin/C-peptide ratios in both tirzepatide (all doses) and dulaglutide compared to placebo [66]

Vitamin B12 injections for direct absorption Oral or sublingual B12 supplements in milder cases Regular monitoring to ensure levels return to normal For individuals with absorption issues, injections are often the most effective approach

Mounjaro is typically prescribed for patients prioritizing blood sugar regulation and metabolic stability, while Zepbound is prescribed for those focused on weight loss