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The study was conducted according to the guidelines of the Declaration of Helsinki

doi:10.1093/jn/137.10.2258

Acrolein contributes to the development of diabetic nephropathy by promoting the accumulation of extracellular matrix, increasing the production of angiotensin II (Ang II), activating MAPK signaling pathways that phosphorylate JNK, ERK, or p38, increasing the expression of inflammatory cytokines such as IL-6, IL-1beta, IL-18, and TNF-alpha, and cleaving caspase 9, caspase 3, and PARP (119)

For the histological analysis, the examiner histologist used the Leica Application module connected to the full HD microscopic imaging system Leica Microsystems GmbH, Germany to determine the mean positive reactive macrophage count of CD163- and CD86- in immunohistochemically stained sections

Slows gastric emptying Food stays in your stomach longer, keeping you fuller between meals and reducing the urge to snack