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Hexarelin is the most potent GH secretagogue but also the least selective

HirasawaATsumayaKAwajiTKatsumaSAdachiTYamadaMet al

Estrogen Deficiency and the Origin of Obesity during Menopause. BioMed Research International , 2014, Article ID 757461

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Numerous studies have demonstrated that E2 exerts an inhibitory effect on HIF-1 expression (17, 28, 68), aligning with the mechanisms through which OSAHS induces cellular autophagy, suggesting that E2 may modulate autophagy via the HIF-1 pathway