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These pathways include the cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis 1,4 , the ferroptosis suppressor protein 1 (FSP1)/coenzyme Q 10 (CoQ 10 ) axis on the plasma membrane 5,6 , the guanosine triphosphate cyclohydrolase 1 (GCH1)/tetrahydrobiopterin (BH4)/dihydrofolate reductase (DHFR) axis 7,8 , and the mitochondrial dihydroorotate dehydrogenase (DHODH)/CoQ system 9

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The FDA's 2023 Category 2 classification specifically restricts compounding pharmacies, while dietary supplements are regulated under DSHEA through a different pathway