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The primary mechanism is sudden metabolic stress

GLP-1s are naturally-occurring hormones in the human body released from the gut after eating, and according to Mayo Clinic, GLP-1 medications are used to boost the amount of insulin our bodies make to keep our blood sugar within a normal range, as well as provide the sensation of fullness after a meal to curb cravings

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However, the specific mechanism of this process remains unclear, and the specific role of the antioxidant Se in this process needs further research to clarify

However, separate analyses suggest Novo's oral semaglutide achieved higher percentage weight loss in obesity trials