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Short answer: Without independent comparative data, direct superiority claims can't be made

OMIM # 616268 [Arboleda et al, 2015

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The label states semaglutide may cause fetal harm, directs discontinuation when pregnancy is recognized for patients treated for cardiovascular risk reduction or weight reduction, and advises discontinuation at least two months before a planned pregnancy because of semaglutide's long half-life

The drug undergoes significant first-pass hepatic metabolism, in which a portion of the absorbed Estradiol is metabolized before reaching systemic circulation