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Zhuo, G

[3] Initial dosing for moderate vasomotor symptoms typically ranges from 1 mg to 5 mg intramuscularly every three to four weeks, with some clinicians favoring a midpoint 2.5 mg monthly regimen and titrating upward or downward according to symptom relief and serum estradiol targets

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It can be seen that the surfaces of NAP and the metabolite NAP-SU abound most in electron-deficient regions