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At an 8-year follow-up, the intervention groups average weight loss was 4.7%, with about 50% losing 5% or more and 27% losing 10% or more of their body weight [854]

A not-insignificant number of patients experience some level of nausea, stomach pain, or general GI discomfort while on Accutane

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It should be noted that there is insufficient evidence regarding the safety of l-carnitine as a supplement during pregnancy, and although small amounts may be safe during breast-feeding, large doses should be avoided

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