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The studys findings are evidenced by a complete renal response (CRR) in 12 patients (66.7%) and an overall response (OR) in 13 patients (72.2%) within the combined treatment group
Key experimental observations include: Preserved Bone Formation: Rodent models demonstrate maintained periosteal activity and longitudinal growth rates despite controlled dosing, indicating localized skeletal responsiveness without broad endocrine activation
J.ReidG.GibsonG
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