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Furthermore, the credibility of the findings should be regarding the possibility that the final endpoint of these concepts (cytoprotection organoprotection [41,42,43,44,45,46,47,48,49], reestablished body homeostasis [59,60,61]), response as such as claimed by both Robert and Selye [41,59], could ever be realized by the pharmacologic agent

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Intradermotherapy and Platelet-Rich Plasma A significant challenge in treating melasma is the low permeability of water-soluble substances through the hydrophobic layer of the stratum corneum