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In the gut-brain axis, unique neural pathways like vagus nerve signaling and serotonin modulation influence neurodegeneration, differing from the gut-liver axiss portal vein transport of bile acids and LPS, affecting FXR/TGR5 for lipid homeostasis in NAFLD

The highly dynamic nature of palmitoylation contrasts significantly with the relatively static nature of similar lipid modifications, such as myristoylation[168]

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Red yeast rice ameliorates non-alcoholic fatty liver disease through inhibiting lipid synthesis and NF-B/NLRP3 inflammasome-mediated hepatic inflammation in mice

Therefore, its essential to also check for depression when treating patients with chronic pain