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Carla Alessandra Scorza has received funding from The National Council for Scientific and Technological Development (CNPq #302583/2017-3)

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Metformin, commonly used for insulin sensitization in metabolic health protocols, lowers fasting insulin and may improve GH pulsatility indirectly [18]

After 8 weeks of hyperglycemic state, further pathological changes of diabetic C57B/6 mice in microvascular structure can occur, including expansion of the mesangial matrix of renal microvasculature and rupture of the renal tubular epithelium 321 The retinal ultrastructure changes, infoldings in retinal pigment epithelium layers are decreased, and balance or proprioception are impaired due to neurovascular disease