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K ATP , channel ATP-sensitive potassium channel, MBF, microvascular blood flow

Targeting the gutimmunebrain axis for therapeutics The gutimmunebrain axis has emerged as a crucial target for developing novel therapies for neurological disorders, with increasing evidence underscoring its role in neuroinflammation, immune regulation, and brain function

The PI3K/Akt pathway involved in insulin signaling also regulates dopamine clearance by modulating dopamine transporter expression and function

However, the decreased HDL cholesterol and apoA1 concentrations induced by modified fasting are contradictory to that reported in previous studies [38, 40] which showed that these parameters increased during the zero-calorie fasting period

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