doi: 10.1097/QAD.0000000000003965
In PIONEER 5, all eligible patients had moderate renal impairment, and overall, renal function was unchanged during the trial period in both groups once the median eGFR ratios (week 31 follow-up relative to baseline) were similar in both groups [HR 1.02, 95% CI 0.271.96 (oral semaglutide)
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During the item generation and discussion and clarification phases, the experts identified 14 distinct challenges: costs, supply challenges, lack of evidence, polypharmacy, barriers to prescription, lack of knowledge, adherence concerns, aversion to injection therapy, clinical inertia, titration needs, perceived health state, fear of adverse effects, lack of clinical guideline recommendations, and lack of measurable outcomes to guide therapy