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Conclusions and path forward Proper integrity and functionality of the proteome, referred to as proteostasis, are essential for coordinating cellular demands and mitigating various intrinsic and extrinsic perturbations, including increased protein synthesis, ERCa 2+ depletion, dysregulated redox homeostasis, energy deprivation, hypoglycemia, hypoxia, and inflammatory stimuli, thereby ensuring tissue integrity and organismal health

Regarding clinical endpoints, meta-analyses showed reductions in the incidence of all-cause mortality, ventricular arrhythmia, and anginal episodes

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