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The production of IL-2 and IL-18 by inflammatory epidermal dendritic cells (IDEC) or eosinophils and the subsequent activation of Th1 cells facilitate the transition to the chronic inflammatory phase with the production of TNF, IL-2, IL-12, INF (52)

Therefore, preventing anaemia by addressing riboflavin insufficiency becomes a crucial aspect, which necessitates assessment and intervention studies on a population-based level [104]

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Knowing grade differences also reduces safety and handling risks