For people with genetic variants that cause more of an impact on CYP1B1 upregulation combined with an inability to eliminate the estrogen metabolites fast enough (due to phase II genes, diet, and lifestyle) then cigarette smoking is going to significantly increase the bad estrogen metabolites
The rapid rise of GLP-1 has disrupted the $40+ billion U.S
Eur J Nutr (2020) 59(7):285774
DNA synthesis is fairly rare in healthy adult mammals, being restricted to repair, mitochondrial renewal, and genome replication for a small subset of cells, including immune cells, germ cells, cells of the hair follicles, some intestinal epithelial cells, and a few others
DSIP is named for its relationship with delta sleep the deepest, most restorative phase of the sleep cycle