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Homozygosity for these rare mutations results in combined deficiency of vitamin K-dependent clotting factors type 2 (OMIM #607473), which is responsive to oral administration of vitamin K

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Environ Pollut 225:559568 Yang JF, Ying GG, Zhao JL, Tao R, Su HC, Chen F (2010) Simultaneous determination of four classes of antibiotics in sediments of the Pearl Rivers using RRLC-MS/MS