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Smith and Clarke, 2010)

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Specifically, watch for burning or stinging sensations when clothing touches your skin, pain when water hits your skin during a shower at normal temperature, discomfort from bedsheets or blankets resting on your body, pain from light touch such as a pat on the back or a handshake, burning sensation from mild temperature changes that previously felt normal, and widespread skin tenderness that is not localized to the injection site

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Separation of these ionic salts and other polar excipients (e.g., glycerol, mannitol, sucrose, etc.) is feasible and straightforward using HILIC