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It is characterized by fever, eosinophilia, urticaria, enlarged lymph nodes, cough, bronchospasm, wheezing, abdominal pain, headaches, and/or hepatosplenomegaly

Dry mouth is another major concern

The authors conclude: In the STEP TEENS trial, treatment with semaglutide 2.4 mg once weekly for 68 weeks was associated with a significant reduction of levels of the liver enzyme alanine aminotransferase compared with placebo. Dr Weghuber adds: Fatty liver disease is the most frequent liver disease in adolescents with no drug therapy currently available

This approach aims to reduce side effects by maintaining more stable drug levels

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