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2002: Leyden et al

Chronic neuroinflammation arises when persistent stimuli, including genetic mutations, pathological protein aggregates (e.g., A and -synuclein), traumatic injury, or neurotoxic exposure, convert an otherwise transient, protective inflammatory response into a sustained and maladaptive state

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Use with caution in patients with kidney disorders where high-dose Vitamin C is not advisable

Decker: Pain related disease states, Towson University, MD, USA Shen CL, Dunn DM, Henry JH, Li Y, Watkins BA (2004) Decreased production of inflammatory mediators in human osteoarthritic chondrocytes by conjugated linoleic acids