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Muoio DM (2014) Metabolic inflexibility: when mitochondrial indecision leads to metabolic gridlock

(2012) further revealed that feeding with a diet containing -tocopherol promotes fracture healing and preserves bone mass in the estrogen-deficient rat

What we know about extended use The longest controlled human trials ran for 12 weeks

Women have higher reported rates than men, likely due to anatomical factors affecting vaginal fungal exposure

The resulting increase in intracellular NAD+ availability activates sirtuins particularly SIRT1, which regulates insulin sensitivity, gluconeogenesis, cholesterol synthesis, and fatty acid oxidation, and SIRT3, which governs mitochondrial antioxidant defences and energy metabolism